03573cam a2200421 i 4500 1013976179 TxAuBib 20231024120000.0 230525s2023||||||||||||||||||||||||eng|u 2023020863 9780593443163 hardcover 0593443160 hardcover TxAuBib rda Karikó, Katalin,. Breaking through : my life in science / Katalin Karik. First edition. New York : Crown, [2023] xiv, 320 pages, 8 unnumbered pages of plates : illustrations (mostly color) ; 22 cm. txt rdacontent n rdamedia nc rdacarrier sti rdacontent rdamedia rdacarrier Prologue - A butcher's daughter -- An extremely brief interlude on science -- A sense of purpose -- An outsider inside the system -- Susan's mom -- A changed world -- Epilogue. "A story of perseverance and the power of convictions from the groundbreaking immigrant scientist whose decades-long research led to the COVID-19 vaccines. Katalin Karikó had an unlikely journey. The daughter of a butcher in postwar communist Hungary, Karikó grew up in a one-room home that lacked running water, and her family grew their own vegetables. She saw the wonders of nature all around her and was determined to become a scientist. That determination eventually brought her to the United States, where she arrived as a postdoctoral fellow in 1985 with $1,200 sewn into her toddler's teddy bear and a dream to remake medicine. Karikó worked in obscurity, battled cockroaches in a windowless lab, and faced outright derision and even deportation threats from her bosses and colleagues. She balked as prestigious research institutions increasingly conflated science and money. Despite setbacks, she never wavered in her belief that an ephemeral and underappreciated molecule called messenger RNA could change the world. Karikó believed that someday mRNA would transform ordinary cells into tiny factories capable of producing their own medicines on demand. She sacrificed nearly everything for this dream, but the obstacles she faced only motivated her, and eventually she succeeded. Karikó's three-decades-long investigation into mRNA would lead to a staggering achievement: vaccines that protected millions of people from the most dire consequences of COVID-19. These vaccines are just the beginning of mRNA's potential. Today, the medical community eagerly awaits more mRNA vaccines-for the flu, HIV, and other emerging infectious diseases. Breaking Through isn't just the story of an extraordinary woman-it's an indictment of closed-minded thinking and a testament to one woman's commitment to laboring intensely in obscurity-knowing she might never be recognized in a culture that is more driven by prestige, power, and privilege-because she believed her work would save lives"-- Publisher. 20231024. Karikó, Katalin. Women biochemists United States Biography. Biochemists United States Biography. Women immigrants United States Biography. Immigrants United States Biography. Hungarian Americans Biography. Hungarians United States Biography. mRNA vaccines Development. COVID-19 vaccines Development. Autobiographies.